The ABC understands that the youngest Ibrahim brother, Michael, was arrested in Dubai this morning and police are now searching the homes of Fadi and John in Dover Heights.
In simultaneous operations, nine men and a woman were arrested in Sydney on Tuesday and five men were arrested in the United Arab Emirates by Dubai police, according to the AFP.
Australian Federal Police have destroyed two drug importation syndicates operating across Australia, Dubai and the Netherlands, resulting in 17 arrests and the seizure of more than 1.9 tonnes of narcotics destined for Australian streets.
Mr Ibahim's son Daniel, 26, will face a Sydney court on Wednesday charged with a range of offences, including conspiracy to import drugs and dealing in the proceeds of crime.
Australian Federal Police and NSW Police have carried out dawn raids at properties across Sydney.
The haul, seized in the Netherlands last month, included 1.8 tonnes of MDMA, 136kg of cocaine and 15kg of crystal meth.
Mr Gaughan said there were connections at the lower end of the two Australian groups and no suggestion of business rivalries.
"The people we allege are part of this syndicate are Middle Eastern organised crime figures that are well-known to law enforcement, and for decades this group has flaunted their wealth and activities, telling the community they were untouchable".
John Ibrahim's model girlfriend, Sarah Budge, 27, is not involved in the drug-smuggling syndicate but faced court on firearms and ammunition charges.
A NSW police spokesperson said a number of search warrants had been issued. "Today, it should be obvious that they are not".
Almost two tonnes of ecstasy bound for Australia has been seized in the Netherlands as part of a massive police sting that netted members of Sydney's most high-profile underworld families.
'I think there is a perception by Australian criminal syndicates that they can operate in certain countries and be out of the reach of Australian law enforcement, ' Mr Gaughan said, reported Fairfax Media.
Extradition proceedings from Dubai are expected to be completed within 60 days.