Rookie Ryan Anderson, Lynden Trail and Chris Carter will each see extended playing time in the absence of veterans. He didn't talk to reporters after the game, but Murphy left the visitors' locker room on crutches with his left knee heavily wrapped.
Murphy was previously slated to miss the first four games of the season after being suspended for violating the National Football League policy on performance-enhancing substances.
According to NFL Network's Mike Garafolo, Murphy will serve his four game suspension while on Injured Reserve.
Murphy is coming off his best season as a professional, collecting nine sacks in 2016. The Redskins have stalwart Ryan Kerrigan as a starter but are presently without a healthy Preston Smith or Junior Galette. A full-time starter previous year, Smith saw his pass-rushing productivity decline.