Tulane's first four drives after halftime ended in punts and netted just 40 yards total.
It moved 52 yards in 12 plays, converting a pair of third downs and a fourth-and-short, on its third series and appeared on the verge of going ahead yet again with a first down at the Oklahoma 27.
While the Sooners' offense was once again running on all cylinders, Tulane's spread option gave Oklahoma fits early before the Sooners settled in late in the first half. Quarterback Johnathan Brantley had great moments, but the interception changed the game.
Tulane took advantage of any distractions and pounded the ball on the ground fairly successfully through the first quarter. The Sooners outscored the Green Wave 35-0 after the targeting call.
Baker Mayfield passed for 331 yards and four touchdowns as No. 2 Oklahoma followed its impressive victory at Ohio State with a 56-14 win over Tulane on Saturday. Nickelback Jarrod Franklin recovered at the Tulane 25, setting the offense into motion. The game was tied at 14 at the start of the second quarter.
The flag was thrown while Lamb was blocking on a reverse to Jeff Badet that would have been a 44-yard touchdown run.
Lamb was open again in the middle for a 22-yard score as Oklahoma tied it at 14.
The crimson and cream momentum continued in the final quarter, this time Jordan Smallwood was the recipient of an 11 yard pass from Mayfield to score. His 82-yard touchdown reception in the first quarter was the longest catch by a freshman in school history. Oklahoma's lightning-paced offense eventually rolled to 631 yards, including an 87-yard touchdown pass with 2:42 left.
Brantley finished 5 of 9 for 43 yards.