The defender said: "We are very optimistic ahead of today's game; we are condemned to beat them because we know Nigerians back home expect the best from us".
The result leaves Nigeria with two points in Group A while Guinea earned their first point.
Nigeria: 1. Esenwa, 2. Ifeanyi (17. Ashadi 62'), 10. Gabriel (9. Okpotu 76'), 18.
After struggling to beat Gambia in the first round of the WAFU Cup of Nations, Ghana showed more hunger and determination to get their group stage campaign off to a flying start.
In 19th minute Guinea manufactured their first opening when Seydouba Camara found himself in space 20-yards out, but his shot shaved the wrong side of the post.
On the stroke of half time Ghana came close again when Gideon Waja let fly from range, but again the direction was poor and the shot sailed over.
Mali should really have taken the lead ten minutes into the second half when a cross from the right was spilled by the Ghanaian keeper into the path of Oumar Kida, but he fired wide from 18-yards out with an empty net gapping.
In fact, the Black Stars only had one attempt on goal in the opening half despite having nearly 70 percent of the possession - that shot coming in the 17th minute courtesy of a strike from Emmanuel Lomotey, but his effort was a tame one and easily saved.
Stephen Sarfo and Kwame Kizito scored two second half goals for Ghana who recorded their second victory in the competition. Frimpong, 12. S. Safro, 5. Adams 91'), 15. K Safro (13. A Camara, 4. N Camara, 5. Keita (7. Sory Camara 63'), 9 I Camara.