Colts quarterback Andrew Luck has been out all season due to a lingering shoulder injury and Titans quarterback Marcus Mariota did not play last week due to a hamstring injury.
Two Titans players - safety Jonathan Cyprien and rookie wide receiver Corey Davis, who are also battling hamstring injuries - have been ruled out of Monday's game, while linebacker Daren Bates (knee) is questionable.
The Titans are likely looking at this matchup as a "get right game" where they can make a solid defensive effort, while getting their running game going again and getting Mariota back into a rhythm. He had been considered day-to-day with the injury since getting hurt, so the Titans signed free-agent quarterback Brandon Weeden earlier this month as insurance while backup Matt Cassel took over the offense.
Below are the results for this weekend's game and the schedule for Week 7 (all times Eastern).
The Titans (2-3) have lost their last two games, but thanks to competing in the weak AFC South, they trail the Jacksonville Jaguars and Houston Texans by one game and could move into a tie for first place with a win against the Colts. Can he play and not risk himself further injury?
A former No. 2 overall draft pick and Heisman Trophy victor at Oregon, Mariota has 792 passing yards, which ranks 30th in the National Football League, three touchdowns and three interceptions in four games this season. He'll likely limited to being a pocket passer, but able to move around in the pocket to avoid sacks and big hits.
Having Mariota on the field against the Colts, even if he's at 80 percent, is far better than having Cassel start.