The FBI said the operation included 55 FBI field offices, 78 state and local task forces and global partners in Canada, the United Kingdom, Thailand, Cambodia and the Philippines.
While 84 minors were recovered during the four-day operation, the Federal Bureau of Investigation said 120 sex traffickers were arrested across the country.
The youngest victim was a 3-month-old, the agency, along with the National Center for Missing and Exploited Children, announced Wednesday.
"The primary goal is really the recovery of children. We know we won't ever be able to eradicate the problem, but our Child Exploitation and Human Trafficking Task Force won't ever give up doing everything we can to save children from the clutches of despicable criminals". "How can we provide some good support for them to keep them out of the life and so that way they don't go back to that?"
The FBI stages operations in hotels, casinos and truck stops as well as online and on street corners.
Several worldwide partners helped as well, including Canada (Operation Northern Spotlight), the United Kingdom (Aident 8), Thailand, Cambodia and the Philippines.
The alleged trafficker was arrested while Child Protective Services are working on finding a secure safe placement for the children.
The Federal Bureau of Investigation led Operation Cross Country XI in 55 FBI field offices across the country with the help of 78 state and local task forces and five global partners hailing from Canada, the United Kingdom, Thailand, Cambodia and the Philippines, according to a press release Wednesday.
The FBI and its partners made contact with young women and adults involved in prostitution through the use of undercover agents and detectives canvassing websites that advertise prostitution and areas known for prostitution. They also have access to medical and mental health counseling as well as other services. "Unfortunately, the number of traffickers arrested - and the number of children recovered - reinforces why we need to continue to do this important work", said FBI Director Christopher Wray in a statement. Since the program's inception, more than 6,500 children have been identified and recovered. Both female subjects have been arrested on federal charges, according to the FBI. Shortly thereafter, the agent met with a 21-year-old female, who offered a fee of $200 to engage in sexual intercourse with her and another female, the 16-year-old victim.