The 29-year-old suffered a hamstring injury in the 3-3 friendly draw with Belgium last week and was subsequently withdrawn from the squad for the second global against Japan. West Ham will have to however pay compensation to Espanyol at the end of the season should they wish to recruit him.
Moyes said striker Javier Hernandez, who is now out with a suspected hamstring injury, need not fear being excluded as he was at Manchester United under him. The West Ham fans were fantastic to me and I'm looking forward to coming back.
James Collins, Michail Antonio, Sam Byram, Jose Fonte and Doneil Henry are all expected to miss the game with injuries suffered prior to Moyes' arrival.
Moyes has started to put his backroom team together with former Norwich City assistant Alan Irvine joining, while Billy McKinlay, now at Sunderland in a caretaker capacity, is expected to follow suit.
Former Everton and United goalkeeping coach Chris Woods remains at the club, having joined in June 2015.
"I'm really looking forward to coming in and getting involved", said the ex-United player who comes into the club after Slaven Bilic was sacked last week.
"The prospect of working in the Premier League, at a great club, and alongside David, meant that it was an opportunity I couldn't resist, and I hope that I can now make a positive contribution".
"I don't think they've got enough men, I think every player has got five per cent more to give and David Moyes has got to find that".
Hernandez has returned from global duty with a hamstring injury.