Real's Ronaldo has made a habit of scoring against Atletico, striking hat-tricks against Diego Simeone's side in La Liga and the Champions League last season.
The Atletico Madrid forward has long been linked with a move to the club, and it seems that while he will be leaving Atletico Madrid this summer, there is another club he had his eye on.
That would be a blow for United, who have courted the player over the last couple of seasons - and they're thought to be unwilling to give up on landing the player just yet.
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As per Real's official site, a number of players like Raphael Varane (ankle) and Mateo Kovacic (groin) have all recovered and are fit to start tonight against their cross-town rivals, having trained with the rest of the squad.
Plus500 will continue as the club's main shirt sponsor, with company branding to remain on the front of Atlético's playing and training jerseys.
Meanwhile, approaching two years on from Zinedine Zidane's appointment as Madrid manager, the Frenchman can still hold claim to winning more trophies during his senior management career than La Liga games lost.
'[Griezmann] does look committed to Atletico.
Simeone also doused rumours about the alleged unrest of star striker Antoine Antoine who's been reportedto have agreed a €90million switch to Barcelona at the end of the season.
Should Atletico avoid defeat to their neighbours this evening, it will mark their longest unbeaten run to start a league campaign, but that does not quite tell the whole story. The club and I want the best, we want committed players.
It is a move to further bolster their attack following the world-record transfer of Neymar to Paris Saint-Germain for £198m in the last window.
We look forward to continuing our journey with them in our new home at the Wanda Metropolitano stadium.
Barca, however, who signed Ousmane Dembele from Borussia Dortmund for £96m, are set to splash the eye-watering fee to bring the France international to the Nou Camp.