That news came about after UEFA, by means of a random draw, announced the host city pairings for the tournament which will begin on 12 June, 2020.
UEFA also picked Rome to host the opening game of the 24-team tournament. This is in addition to the semifinals and final, which were already set for Wembley.
Staged across 12 countries, Euro 2020's unusual format was former Uefa president Michel Platini's brainchild - a one-off gesture to celebrate the tournament's 60th birthday. "They had time until today's executive committee (meeting) and they didn't do it".
Wembley will now host seven matches, including the two semi-finals and the final on July 12, 2020.
But the exclusion of Brussels means the 90,000-seater venue will also get group games and a match in the first knockout round.
Rome and Baku will host Group A, Saint Petersburg and Copenhagen Group B, Amsterdam and Bucharest Group C, London and Glasgow Group D, Bilbao and Dublin Group E, with Munich and Budapest the Group F venues. The concept of taking Euro 2020 to 13 different countries was devised to allow smaller countries, like Wales, to have a unique opportunity of being involved in staging a major tournament.
The statement concluded by wishing Uefa and Wembley all the best and saying it would now concentrate all its efforts on ensuring Wales qualify.
The governing body made a decision to reallocate the three group-stage games and one last-16 game originally given to the Belgian capital because of delays in the project to build a new 60,000-capacity Eurostadium on the site of Heysel.
Each qualified host country will play a minimum of two games at home.
"This has been a collective and collaborative process and we could not have done it without the support of the Government and the Mayor of London".
Minister for Sport Tracey Crouch said: "With matches being played across Europe, for the 60th anniversary of the competition, it will be a very special tournament and I know that we will give fans a warm welcome when they visit England's iconic national stadium".
Khan said: "It speaks volumes about our great city that London has been awarded an additional four Euro 2020 matches, reinforcing the capital's reputation as the sporting capital of the world".