The Creek Fire is continuing to grow in the Angeles National Forest south of Santa Clarita even as firefighters continue establishing containment around the burn area.
More than 230,000 people have had to leave their homes in Los Angeles and Ventura counties.
By midday, the fire had burned 11,000 acres and jumped the 210 Freeway.
I-405 is a heavily traveled thoroughfare by both commuters and by freight haulers along its entire length and is the busiest and most congested freeway in the United States.
"These are days that break your heart".
Mandatory evacuation orders have been issued for residents within the following boundaries: South of Mulholland Drive, east of the 405 Freeway, north of Sunset Boulevard and west of Roscomare Road. Roughly 30 structures have been destroyed, 20 in the Kagel Canyon area and 10 in the city of Los Angeles, L.A. fire officials said.
The massive blazes showed no signs of stopping as roaring winds fueled flames that feasted on the tinder-dry conditions in the region.
Mandatory evacuations were in place for parts of Bel Air and at least four homes were already destroyed, the Los Angeles Times reported. The 405 freeway was later reopened, transportation officials said. More than 125 firefighters are on the scene, and water-dropping helicopters are being deployed.
It has been reported that Rupert Murdoch's Bel Air estate is in the line of fire. "The sky was bright orange".
Personnel at Santa Anita Park in Arcadia on Wednesday let its Twitter followers know they had reached capacity for accommodating horses and re-Tweeted Fairplex's Twitter post, notifying followers the fairgrounds could house their animals.
"We will take any other small livestock such as llamas, chickens and pigs", Hernandez said. Air filtration systems are protecting the galleries from smoke. "The buildings themselves are made of travertine and metal panels".
"Now, everything that I have, except for my lovely family, is gone", she said. "Prayers to all affected by these fires".
Over the weekend, there have been three fires raging in the Los Angeles area - in Ventura County, Bel Air, and the northeastern San Fernando Valley. It started Monday evening in a rural area and spread to the city. "Right now we're at a hotel".
If the wind dies down, firefighters will be able to get a handle on the blazes, the chief said. The institutions' Torah scrolls were removed for safekeeping, according to the report.