He latched onto a through ball from Marco Asensio to confidently sidefoot the ball inside the near corner to score Real's second goal midway through the first half and then powered home the third from the penalty spot, his shot bouncing under Sevilla goalkeeper Sergio Rico.
"Of course I feel happy; this is something I look forward to every year", Ronaldo said at the ceremony at the Eiffel Tower in Paris.
Centre-back Varane limped off in the 38th minute of Real's 3-2 Champions League win over Borussia Dortmund on Wednesday, and his time on the sidelines comes as Zidane has to deal with a defensive crisis ahead of Sevilla.
TWITTER FRANCE FOOTBALL The 32-year-old was given a standing ovation by his peers during the ceremony
Portugal captain and victor of the 2017 Ballon d'Or, Cristiano Ronaldo, has declared himself the best footballer in history.
The former Real playmaker added: "He'll always be up here for me". I hope we can keep scoring, we've scored eight goals in our last two games and we have to keep going like this.
Click through the gallery above to see the top 15 in this year's Ballon d'Or ranking, and let us know if you agree with the final results in the comments section below!
"I don't see anyone better than me", Ronaldo, 32, told France Football.
Messi followed in second place with 670 points, which calculates to 23.91% of the votes, while Neymar completed the podium with 361 points, or 12.88%.