During their time on the space station, the group managed hundreds of science experiments in a variety of fields, including planetary science, physics, microbiology, biotechnology and genetics.
Highlights from the research conducted while they were aboard include investigations of microgravity's effect on the antibiotic resistance of E. coli, a bacterial pathogen responsible for urinary tract infection in humans and animals; growing larger versions of an important protein implicated in Parkinson's disease; and delivering a new instrument to address fundamental science questions on the origins and history of cosmic rays.
The three also saw several cargo ships come and go.
Three crew members of worldwide space station are set to return to Earth under rapid-crew rotation process.
The fresh crew members - Soyuz MS-07 commander Anton Shkaplerov, NASA flight engineer Scott Tingle and Japanese physician-astronaut Norishige Kanai - will reach the outpost early Tuesday, joining Expedition 54 commander Alexander Misurkin and NASA astronauts Mark Vande Hei and Joe Acaba. Ryazanskiy has also executed two expeditions, but has spent 306 days in space.
Bresnik has now completed two stints aboard the space station, logging 150 days in space.
On December 17, Scott Tingle of the USA space agency NASA, Anton Shkaplerov of Russia's Roscosmos, and Norishege Kanai of the Japan Aerospace Exploration Agency are scheduled to blast off from Baikonur to join the ISS crew.
The Soyuz MS-05 capsule carrying the crew of Paolo Nespoli of Italy, Sergey Ryazanskiy of Russian Federation and Randy Bresnik of the U.S lands in a remote area outside the town of Dzhezkazgan (Zhezkazgan), Kazakhstan, December 14, 2017. NASA Television will broadcast the launch and docking.