West Brom, however, will enter Sunday's match with some belief having collected a point at Liverpool on Wednesday night.
Last season, the Baggies managed a goalless draw at Old Trafford, but United claimed a 2-0 win in the corresponding fixture.
In 17 seasons of management, Mourinho has won eight domestic league titles, while he has also picked up two Champions Leagues and a couple of Europa League titles. A total of 14 points has left them just outside of the relegation zone on goal difference, while only Swansea have a worse home record at this stage of the campaign.
The Red Devils will make the trip to West Brom in search of another three points and more importantly an improved performance following their disappointing display in a 1-0 victory over Bournemouth mid-week.
As for West Brom, Gareth Barry could return after recovering from a thigh problem but Matt Phillips, Craig Dawson, Nacer Chadli and James Morrison are all out.
Jonny Evans will captain the Baggies against his former club, while James McClean is expected to keep his spot in a wide area as Salomon Rondon leads the line once again.
Mata should start in the No.10 role behind Lukaku and the likes of Lingard and Martial should start out wide in the attack. West Brom should fight hard and that should ensure that a low scoring game is the result.
A draw is available at 3/1 odds at most bookmakers, and a home win can get you up to 6/1 odds at BetVictor.