Winfrey's speech was praised and some suggested that she should run for office in 2020.
Media outlets - especially right-wing ones - have resurfaced pictures that Winfrey would probably prefer stay hidden of her palling around with the disgraced Hollywood producer, who has been accused of sexually harassing or abusing more than 80 women.
Publicly, Winfrey has denounced Weinstein's "hideous behavior".
According to a report from Page Six, actress Kadian Noble said that Weinstein used his connection with Winfrey and Naomi Campbell to give her the impression he could help her rise to fame. "Actually, I think I'd be a better president than Oprah and Susan Sarandon, probably even President Trump". Her speech touched on her upbringing, being raised by a single mother, growing up disenfranchised and how her platform has given her more of a voice.
Weinstein continues to deny all the allegations against him.
Meryl Streep and Matt Damon have also been criticized for claiming they didn't know about Weinstein's alleged sexual misconduct. In her speech, Oprah declared that "a new day is on the horizon" for women and girls, and called for a time "when nobody ever has to say "me too" again".
Winfrey concluded her speech by mentioning the #MeToo movement. "I don't think she's going to run".
"If we make this just about Harvey Weinstein, then we will have lost this [watershed] moment", she told CBS This Morning in an October interview. He didn't touch me. "For too long, women have not been heard or believed if they dared to speak their truth to the power of those men, but their time is up".
On Sunday, Winfrey was awarded [VIDEO]with the Cecil B. DeMille award, recognizing her accolades of excellence in the TV and entertainment business. But when the accusations against Weinstein surfaced, she didn't offer a very personal answer.