Trump will be the first American president to attend the Davos World Economic Forum since former President Bill Clinton.
"I don't think it's a hangout for globalists", Mnuchin said at the White House daily press briefing.
Treasury Secretary Steve Mnuchin, who will lead the administration's economic delegation, on Thursday brushed aside portraits of the annual forum as a gathering of elite proponents of globalization, a characterization previously made some former Trump advisers.
Secretary of State Rex Tillerson and Energy Secretary Rick Perry are also attending the World Economic Forum the week of January 22 but as part of a separate US delegation, one of the people said. Among other members of the presidential delegation are the Secretary of State Rex Tillerson, Commerce Secretary Wilbur Ross, Labour Secretary Alex Acosta, Energy Secretary Rick Perry, Transportation Secretary Elaine Chao, and Kirtstjen Nielson, Secretary of Homeland Security.
Considering President Donald Trump's platform of economic populism and fighting for the working class, his decision to attend has raised eyebrows.
Mnuchin said that Trump would talk about "reciprocal, free, and fair trade" at the summit.
White House press secretary Sarah Huckabee Sanders says in a statement that the president welcomes the opportunity to promote his "America First" agenda with world leaders.
The delegation is larger than the one that accompanied Vice President Joe Biden in 2016, a group that included six Cabinet secretaries and drew notice for coming during the Obama administration's lame duck year.