For Burnley team, Jonathan Walters has undergone knee surgery and he will not for next few months and also without Chris Wood and left-back Stephen Ward. Only centre-back Eric Bailly and striker Zlatan Ibrahimovic are among the notable absentees, per Sheridan.
Burnley haven't lost three consecutive home Premier League games since April 2010, when they lost four in a row under Brian Laws.
"That's how hard the Premier League is".
Burnley have won only one of the last 24 meetings in all competitions - a 1-0 Premier League triumph in August 2009.
Michael Carrick returned to training (heart condition) during United's pleasant warm weather Dubai training trip, but it remains to be seen if he'll be ready to go for this one. Burnley have not won a game since December, which is part of a seven game run without victory.
So it may not be the best time for the "Ginger Mourinho", as Dyche used to be nicknamed, to face the actual Jose Mourinho.
The reverse fixture, at Old Trafford, ended in a 2-2 draw but Jose Mourinho's side have picked up seven points in the three league games since that fixture. City was going off at -10000 to win the league title and looked invincible at 20-0-1, but that invincibility is no longer intact after the club played to a draw against Crystal Palace and lost outright 4-3 to Liverpool last weekend.
They could lose their opening four competitive matches of a calendar year for the first time since 1987.
Burnley are winless in all 49 Premier League matches under Sean Dyche when they have conceded the opening goal, losing 39 of them.
The clash with United will also represent a special milestone for Dyche, who will be managing his 100th Premier League game. Manchester United is going off at +3300 to win the league championship, followed by Liverpool (+4500), Chelsea (+10000), and Tottenham Hotspur (+12500).
United have claimed 13 points from five away matches and scored 13 goals in the process.
Romelu Lukaku's place seems more secure than most, and he has scored in his last two games.
Probability of away win: 57%.