This is the second time that Dr Rouhani is visiting Hyderabad, and the first visit after assuming office as the President in 2013.
India, Iran and Afghanistan have already signed an agreement to give Indian goods, heading toward Central Asia and Afghanistan, preferential treatment and tariff reductions at the Chabahar port city in southern Iran.
Iranian President Hassan Rouhani will be seeking billions of dollars of Indian investment during a visit to New Delhi, diplomats said, a trip that comes amid USA pressure to review a 2015 global nuclear deal and re-impose sanctions on Iran.
Previously in an exclusive interview with BW Businessworld, Afghanistan's Ambassador to India, Dr. Shaida Abdali said, "India, Afghanistan, and Iran worked together for nearly 13 years before realizing the life-changing initiative".
The Iranian Prez is likely to visit historic sites in Hyderabad, including the Qutub Shahi Tombs at Golconda, before leaving for New Delhi.
He noted the visit is made at the official invitation of the Indian Prime Minster Narendra Modi.
Top on the agenda of Rouhani's visit would be the completion of Iran's Chabahar port by India as well as discussions over a potential deal for Indian companies to develop an offshore gas field in Iran.
Development and operationalisation of the Chabahar port in Iran is expected to figure prominently in talks between the two leaders.
India-Iran bilateral trade stood at $12.89 billion in 2016-17, according to figures provided by the External Affairs Ministry.
Speaking to reporters at the Mehrabad Airport in Tehran, Rouhani said he will have meetings with the president and prime minister of India, adding that a number of cooperation agreements will be also signed between the state-run sectors, business people and entrepreneurs of the two countries.