"A Clasico is never just another match", Ramos said, according to RealMadrid.com. It had extra caffeine.
Sergi Roberto received a red card in stoppage time during the first half Sunday at Camp Nou in Barcelona, Spain, meaning he was ineligible to complete the rivalry bout.
Gareth Bale pulled Madrid level again in the 72nd after curling in a pass by Asensio.
For Barcelona coach Ernesto Valverde it was all about maintaining his side's proud unbeaten record this season, while Zinedine Zidane looked to avoid defeat whilst casting an inevitable eye towards the upcoming Champions League final.
"He's not great right now but I think it's going to be a small thing, it was only a bad movement", Zidane told a news conference. "Next year, it will be different with VAR, and we will see how a game like this ends up".
The Wales global was handed a rare start in the game as Real Madrid looked to end Barca's unbeaten record in La Liga.
Barcelona has three matches left to become the first team to go unbeaten in the competition since the 1930s, when it consisted of 10 teams compared to 20 now.
The Barcelona and Real Madrid forwards have scored 551 and 449 goals for their clubs respectively across all competitions.
"It will be a spectacular game, open and with chances for both teams".
Sergi Roberto also impressed, before being sent off. The striker played on until half-time but was substituted during the interval.
The joy at Camp Nou was short-lived.
Ronaldo started the move by teeing up Toni Kroos on the overlap, the Germany midfielder's cross nodded into the middle by Benzema and the Portugal superstar tapped in on the line despite the close attention of Gerard Pique.
Ronaldo appeared to shake off the injury.
Madrid were stamping their authority on the contest, Ronaldo heading over and drilling wide either side of being denied at close range by Marc-Andre ter Stegen. Suarez felt he had been elbowed by Sergio Ramos, prompting the first round of scuffles, before Messi was booked for flying into the defender on the touchline. That preceded Roberto's red card.
Ronaldo stayed on the bench and, without its star, Madrid couldn't impose its numerical advantage. And in the build-up to the Catalans' second goal, Luis Suarez seemed to trip Raphael Varane.