"Who are you and America to tell us to limit the range of ballistic missiles?".
Iran's President Hassan Rouhani dismissed the threats.
The world's experience with regime change in Iraq should make clear why this is a bad idea.
There is no defending Iran's support for Bashar al-Assad, the bloody dictator in Syria, or its use of Hezbollah militants to control Lebanon and threaten Israel.
Instead of suggesting a re-negotiation of the Iran deal, Pompeo outlined 12 tough conditions from Washington for any "new deal" with Tehran to make sure it "will never again have carte blanche to dominate the Middle East".
(L-R) European Union foreign policy chief Federica Mogherini, Iranian Foreign Minister Javad Zarif, French Foreign Minister Jean-Yves Le Drian, German Foreign Minister Heiko Maas and British Foreign Secretary Boris Johnson pose for a photo during a meeting of the foreign ministers from Britain, France and Germany with the Iran Foreign Minister and EU foreign policy chief Federica Mogherini, at the Europa building in Brussels, May 15, 2018.
Under the deal, known as the Joint Comprehensive Plan of Action (JCPOA), the USA and other world powers offered sanctions relief in exchange for Iran giving up its nuclear capability. Perhaps President Trump and his staunchly anti-Iran advisers are hoping that these confrontations between Rouhani and Iran's powerful hardliners may eventually lead to a much desired "regime change" in the country.
"Most European nations are likely to continue their support of the Iran deal because they opposed Trump's ending of that agreement".
Still, many question how effective US sanctions will actually be.
As tough U.S. sanctions kick in later this year, the global economy will have to brace itself for more instability and shock.
It's no surprise that Iran didn't take that well.
Trump's decision to withdraw the us from the 2015 nuclear accord struck between world powers and Tehran has rattled close USA allies in Europe who had been counseling the American president against taking such a unilateral action. Iran has no nuclear weapons and has significantly curbed its program. Pompeo said that the long list of demands was Iran's fault, and that crippling sanctions would bring them back to the negotiating table.
"If they restart their nuclear program, they will have big problems, bigger problems than they've ever had before", he said.
It was a pointed response to Mr Pompeo, who issued a list of 12 demands addressing Iran's policies in the Middle East and its ballistic missile programme following the unilateral USA withdrawal from a 2015 nuclear deal between Tehran and world powers.
Trita Parsi, head of the National Iranian American Council, called most of Pompeo's demands "non-starters".
The Mujahedin-e-Khalq Organization (MKO) is an exiled Iranian armed opposition group which has called for the overthrow of the Iranian government for decades.
It was no accident that Pompeo, who served in the House of Representatives before Trump named him to head the Central Intelligence Agency a year ago, chose the fraught topic of Iran for his first policy speech.
Meanwhile, Pentagon spokesman Colonel Rob Manning said the military was weighing "new actions" to counter Iran's influence in the Middle East, but he stressed this was part of a "whole of government" approach and offered no details. Putin, however, has so far shown no indication that it is ready to abandon Iran to please the U.S. or Israel.