Nicola Sturgeon, Scotland's first minister, who visited the scene today (June 16) says the damage from the latest "heartbreaking" fire is "much, much worse" than the previous blaze.
There have been no reported casualties at a fire at the School of Art in Glasgow, which was due to be reopened next year after a restoration from a previous fire in May 2014.
The fire gutted the 1909 building and spread to two others nearby, a night club and a music venue.
Margaret Archbold, 48, a Glasgow artist who studied fine art at the school and graduated in 1994, said she had come down to the cordons around the building to "say goodbye".
Efforts to bring the fire under control are expected to be "prolonged", Deputy Chief Officer Iain Bushell said.
Last night, the world renowned Glasgow School of Art went up in flames. Heath said the theatre was still on fire and its roof had partly collapsed, but the blaze was no longer spreading.
If you're nearby, here are the buildings affected, as well as any road closures and places to avoid for safety.
The UK government "stands ready to help, financially or otherwise", he added.
Firefighters worked for three days to put out the Victoria's blaze, which forced the closure of several buildings and businesses in the Sauchiehall Street, Hope Street and Bath Street areas.
Fire fighters attended the scene of a second fire at Glasgow's School of Art four years after part of the Charles Rennie Mackintosh designed building was destroyed by fire. "The fire brigade are now on scene", posted the Glasgow School of Art's Twitter account.
He said it was likely that all the restoration work carried out since the last fire had been destroyed.
After spending millions to restore it, the Glasgow School of Art has been devastated by fire once again.
In regards to the Mackintosh building itself, it's been confirmed by firefighters that "extensive damage" has been suffered.
The school's alumni include recent Turner Prize for art winners Simon Starling (2005), Richard Wright (2009) and Martin Boyce (2011).
"This is a very sad morning in the city of Glasgow", she said.
Stuart Robertson, the director of the Charles Rennie Mackintosh Society, said the second fire was "unbelievable".
"The fire brigade are now on scene", tweeted Glasgow School of Art.