Those are all 30-plus and battle-hardened - as are Gilles Simon and the world No 1, Nadal.
Djokovic, seeded 12th following time off with injury, will play Karen Khachanov last on the 11,000-seat No.1 Court.
The 103rd-ranked McDonald, 23, who won the 2016 NCAA singles and doubles titles for UCLA, defeated Guido Pella 6-4, 6-4, 7-6 (6) as the Argentine player featured for a third consecutive day. "But once I get on court, it is just going to be another match, just like my first couple of rounds". I am playing well. He has lost the previous five but impressed in their most -recent meeting, in Basel a year ago, when he won the opening set.
The status quo has been challenged like never before in the women's singles, with nine of the top 10 seeds crashing out before the Wimbledon last 16 for the first time in the Open area.
The 36-year-old American will face another mother in the fourth round Monday: 120th-ranked qualifier Evgeniya Rodina of Russian Federation, who upset No. 10 seed Madison Keys of the U.S. Williams meets the victor of Camila Giorgi and the perennial giant-killer Ekaterina Makarova, who put out the second seed Caroline Wozniacki in the second round.
"I really take every match one at a time, not necessarily as it will be my last, but I try hard every time", Federer told BBC afterward.
It is a remarkable record sure to alarm her opponents, but Williams, seeded 25th after her maternity leave, admits that fear factor can be a double-edged sword.
Pliskova's opponent in the next round, Kiki Bertens, will be brimming confidence after knocking out five-times champion and ninth seed Venus Williams.
The Czech faces Dutch 20th seed Kiki Bertens, who stunned five-time Wimbledon victor Venus in the third round.
"It was an unprofessional attitude from me today".
"Just ran out of time in the end, " Venus said.
Other winners Saturday included Belgium's Alison Van Uytvanck who followed her upset of defending champion Garbine Muguruza by beating Anett Kontaveit, the 28th seeded Estonian, 6-2, 6-3.
Earlier in the day, US Open finalist Madison Keys struggled to find her rhythm in a 7-5 5-7 6-4 defeat to Russian qualifier Rodina.
So while tennis fans around the world start dreaming, hoping and longing that the two most successful players on planet tennis will renew their rivalry on the sport's greatest stage, there is one person who is definitely not keen on the idea.
Meanwhile, 13th seed Julia Goerges, Donna Vekic, Ekaterina Makarova, Camila Giorgi all progressed to the fourth round.