Series stars Danielle Brooks and Adrienne C. Moore, along with the rest of the cast announced the news in an emotional video posted on Twitter.
But she added: 'Season seven you will not be disappointed, it is a season you will not forget and we're going to give you everything and more that you could have ever wanted. thank you, thank you, thank you'.
Actress Kate Mulgrew said she'll miss being with a "groundbreaking" TV series.
While some of the show's seasons have proven more divisive than others, "Orange is the New Black" has been on the receiving end of consistent critical praise over the years, most of which usually focuses on highlighting the strong performances of its cast.
The seventh and final season promises to be somewhat different, too. "My heart is orange but fade to black". Even hardcore followers of the series (like my wife) have said that the last two seasons have dropped off in terms of quality. Created by Weeds creator Jenji Kohan, the show is based on the memoir by Piper Kerman, who like main character Piper Chapman (Taylor Schilling), was locked up in a women's prison.
Though Netflix does not release viewership information, Nielsen has attempted to calculate the show's audience in a continued push to measure streaming viewers.
Reacting to the sad news, Laura Prepon, who plays Alex Vause, said: 'But the one thing is, our relationships will continue after the show'.
The seventh season should be an interesting one for viewers, who watched - SPOILER ALERT - Piper get out of prison in the season six finale.