He called on Mexico to ensure the migrants do not reach the United States border while threatening Guatemala, Honduras and El Salvador with financial penalties.
Mexican television footage showed hundreds of migrants breaking through Guatemalan border posts and streaming onto a bridge connecting Mexico and Guatemala.
Saturday will mark a week on the march for the throng of hopefuls who plan to assemble on the U.S. -Mexico border and demand entry.
In part, the response is meant to both dissuade the migrants from even attempting to enter Mexico and potentially to show the Trump administration that Mexico is willing to, as the government put it, "maintain order".
In another, he suggested that the "onslaught" of immigrants could undermine a recently announced reworked trade deal with Mexico and Canada, writing that immigration is "far more important to me, as President, than Trade". Mexico reportedly responded by sending police to its own southern border to stop the caravan from coming through after the threat was made.
He later thanked Mexico for sending police and riot gear to the Mexico-Guatemala border, saying that the USA looks forward to working with the country. "They came in droves from Guatemala and Honduras through the Mexican border and for years Uncle Sam rolled out the welcome mat offering housing, food, medical treatment and a free education". Trump said on Twitter.
"Until the human rights abuses and violence and deprivations and underlying issues are addressed, people will continue to flee their countries", she told TIME. In April, he said in a meeting with foreign leaders that the U.S.is "going to be guarding our border with our military".
Mexican authorities prepared to receive the migrants and determine who would get refugee status and who will be deported back to their country. More than 150 members of that group crossed the border and sought asylum.
In April, Mexican immigration officials had some success in dispersing the smaller caravan by processing many who chose to seek refugee status in Mexico, but some did continue on to the US border where they were processed over several days.
The row comes as US Secretary of State Mike Pompeo prepares to embark on a tour of the region that will see him visit Mexico ahead of its December inauguration of President-elect Andres Manuel Lopez Obrador, as well as Panama. It wasn't clear if they were taking any action.
He said he had spoken with Honduran President Juan Orlando Hernandez about ensuring the migrants who want to return home can do so safely.
Frustrated by Congress' failure to fully fund his proposed wall, Trump in April ordered National Guard personnel to help secure the border in four southwestern US states.