The drugs were found concealed inside dozens of metal boxes that were declared as "Single Loud Speakers". The shipment also included 25 kilograms (55 pounds) of cocaine and five kilograms (11 pounds) of heroin.
It is the single largest seizure of methamphetamine heading Down Under and the largest domestic bust of the drug on United States soil.
The drugs were seized at the Los Angeles/Long Beach seaport on January 11.
Police say more than 17 million drug deals could have resulted from the amount of methylamphetamine stopped.
Australian Federal Police will hold a media conference on the seizure this morning.
Authorities are warning that worldwide drug syndicates are stepping up efforts to get their drugs into Australia.
Both men are expected to appear briefly in court in Sydney today, where Australian Federal Police officers will apply to have them extradited to Melbourne.
The bust is the third major seizure announced by us authorities in a matter of weeks. "They've been sending smaller amounts over the years, (but) this is now flagging the intent that Australia is being targeted".
"We've got money, and we're willing to pay more for our drugs than anywhere else in the world".
"By stopping this, we have ensured criminals will not profit from the vast pain these drugs would have caused our community", AFP Assistant Commissioner Bruce Hill told reporters. We now believe that Mexican cartels are actively targeting Australia'. Police said they had found "h$3 undreds of thousands of dollars of proceeds of crime" while executing a search warrant of the couple's property.
Australian police indicated that the country's biker gangs, with deep involvement in organised crime, were willing interlocutors. The suspect was linked to organised crime with outlaw motorcycle gangs.
Three people fronted court on Friday on charges including attempted drug importation and possession with the trio remanded for their next appearance on June 17.