The movie, Marvel's first to be featured exclusively by a female hero, is headed toward the second biggest global opening of any superhero movie behind Avengers: Infinity War and the 6th best global box office debut ever.
Captain Marvel is the latest bona fide blockbuster for Marvel Studios, and with little to challenge it over the next few weeks, the sky's the limit for the film's cosmic hero.
The Captain Marvel Saturday box office brings in an estimated $53,037,000, which means the flick is now over $100 million at the US box office.
It also ranks as one of Marvel's most successful character debuts.
Captain Marvel has pummelled the global box office, scoring the sixth-biggest movie debut of all time. Anna Boden and Ryan Fleck have directed the feature.
Female power has reared up at the box office - in a big way.
When compared to other worldwide openings, Captain Marvel falls in 6th place, behind Harry Potter and the Deathly Hallows Part 2, Jurassic World, Star Wars: The Force Awakens, The Fate of the Furious and Avengers: Infinity War, in that order.
But "Captain Marvel" continues a streak of box-office juggernauts about women and people of color.
Superheros rule the big screen these days, and biggest worldwide opening of all time for a female-fronted film is Captain Marvel, and the 2nd-largest for a comic book adaptation.
Of course, Captain Marvel's March opening also means it's facing very little competition.
"I just heard that I was on the cups and popcorn and I wanted to see for myself", Brie told the audience. In North America, the film earned $14.1 million from 411 IMAX runs to mark IMAX's second-biggest domestic March opening ever.
The film garnered an "A" CinemaScore from audiences and a 79% score on review site Rotten Tomatoes.