The company led a slide in industrial sector stocks.
The Dow fell 153.81 points to 25,319.42, but the broader S&P 500 rose 0.3 percent to 2,758.27 and the tech-heavy Nasdaq was up an even stronger 0.7 percent at 7,474.61.
The Dow fell 68 points, or 0.3 per cent, to 25,585.
The Labor Department said its Consumer Price Index (CPI) rose 0.2 percent, in line with estimates, implying benign underlying inflation last month and supports the Federal Reserve's "patient" approach for further interest rate hikes this year.
Britain's Prime Minister Theresa May battled to win support for her plans for an orderly Brexit, but Attorney General Geoffrey Cox dealt a blow saying the assurances she had been given still meant the United Kingdom could be locked in the bloc's orbit after Brexit. Wholesale gasoline fell 1 cent to $1.82 a gallon, heating oil fell less than 1 cent to $1.99 a gallon and natural gas rose 1 cent to $2.78 per 1,000 cubic feet. All three indexes experienced an early setback related to Friday's mixed U.S. Non-Farm Payrolls report and weaker-than-expected trade balance data from China.
The aircraft maker's stock sank 10 percent following the second deadly crash involving the newest version of its popular 737.
Technology and health care companies powered much of the gains Wednesday.
F5 Networks Inc slipped almost 7.4 percent, the most on the S&P index, after the network software maker said it would buy privately held NGINX.
Investors are still waiting for more details on any potential trade deal between the US and China.
Among other stocks, Coca-Cola Co dipped 0.3 percent after HSBC downgraded the soda maker's stock. Costly tariffs have hurt both nations and investors hope a deal can be struck to at least take some pressure off the global economy, which has shown signs of cooling off.
The pound slumped by more than 1 percent against the dollar, to $1.3014, after the British Attorney General's assessment of May's new deal reinforced expectations that lawmakers will reject it Tuesday.
Britain joined a growing number of countries to ground the plane.
USA stocks rose on Tuesday as benign February inflation data supported the Federal Reserve's dovish stance on future rate hikes, but Boeing's fall for a second straight session pressured the Dow.
The dollar fell more steeply shortly after data revealed that the US consumer-price index climbed 0.2% in February, matching market expectations, while the cost of living over the past year slowed again to 1.5% from 1.6%. The euro advanced to $1.1256 from $1.1245. Microsoft added 1.1 per cent and UnitedHealth Group climbed 2.6 per cent.